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Pathophysiology and Treatment of Liver Diseases

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Hepareg
  • Home
  • About
    • About Hepareg
    • Plateforms and CHB
    • Legal notice
  • Projects and teams
    • 1- Modulation of cellular plasticity and liver bioengineering
    • 2- Bioconstruction of hepatic organoids
    • 3- Microbiota, Inflammation and Cancer
    • 4- Biliary homeostasis and hepatobiliary pathophysiology
  • Publications
    • Publications - Team 1
    • Publications - Team 2
    • Publications - Team 3
    • Publications - Team 4
      • Group 1
      • Group 2
      • Group 3
      • Group 4
  • News & events

Job offers

Publications: Team 4 - Group 1 - Thierry Tordjmann

Publications 2026

Plasma membrane Bile acid TGR5 receptor specific stimulation induces Ca2+ mobilisation, ATP secretion and P2Y receptors activation in cholangiocytes.
Chen X, Al-Shebel A, Pebrier T, Tordjmann T, Dellis O.
Biochim Biophys Acta Mol Cell Res. 2026 Jan;1873(1):120067. doi: 10.1016/j.bbamcr.2025.120067.

Publications 2024

Tight junction proteins and biliary diseases.
Merlen G, Tordjmann T.
Curr Opin Gastroenterol. 2024 Mar 1;40(2):70-76. doi: 10.1097/MOG.0000000000000996.

Publications 2023

Hepatic deletion of serine palmitoyl transferase 2 impairs ceramide/sphingomyelin balance, bile acids homeostasis and leads to liver damage in mice.
Lallement J, Raho I, Merlen G, Rainteau D, Croyal M, Schiffano M, Kassis N, Doignon I, Soty M, Lachkar F, Krempf M, Van Hul M, Cani PD, Foufelle F, Amouyal C, Le Stunff H, Magnan C, Tordjmann T, Cruciani-Guglielmacci C.
Biochim Biophys Acta Mol Cell Biol Lipids. 2023 Aug;1868(8):159333. doi: 10.1016/j.bbalip.2023.159333.
Engineered human liver based on pullulan-dextran hydrogel promotes mice survival after liver failure.
Le Guilcher C, Merlen G, Dellaquila A, Labour MN, Aid R, Tordjmann T, Letourneur D, Simon-Yarza T.
Mater Today Bio. 2023 Jan 19;19:100554. doi: 10.1016/j.mtbio.2023.100554. PMID: 36756209; PMCID: PMC9900439.

Publications 2022

Fibroblast growth factor 19 stimulates water intake.
Ursic-Bedoya J, Chavey C, Desandré G, Meunier L, Dupuy AM, Gonzalez-Dopeso Reyes I, Tordjmann T, Assénat E, Hibner U, Gregoire D.
Mol Metab. 2022 Jun;60:101483. doi: 10.1016/j.molmet.2022.101483. Epub 2022 Mar 31. PMID: 35367668; PMCID: PMC9019402.

Publications 2021

Bile acid-receptor TGR5 deficiency worsens liver injury in alcohol-fed mice by inducing intestinal microbiota dysbiosis.
Spatz M, Ciocan D, Merlen G, Rainteau D, Humbert L, Gomes-Rochette N, Hugot C, Trainel N, Mercier-Nomé F, Domenichini S, Puchois V, Wrzosek L, Ferrere G, Tordjmann T, Perlemuter G, Cassard AM.
JHEP Rep. 2021 Jan 19;3(2):100230. doi: 10.1016/j.jhepr.2021.100230. eCollection 2021 Apr. PMID: 33665587

Publications 2020

TGR5 controls bile acid composition and gallbladder function to protect the liver from bile acid overload.
Bidault-Jourdainne V, Merlen G, Glénisson M, Doignon I, Garcin I, Péan N, Boisgard R, Ursic-Bedoya J, Serino M, Ullmer C, Humbert L, Abdelrafee A, Golse N, Vibert E, Duclos-Vallée JC, Rainteau D, Tordjmann T.
JHEP Rep. 2020 Nov 11;3(2):100214. doi: 10.1016/j.jhepr.2020.100214. eCollection 2021 Apr. PMID: 33604531
TGR5-dependent hepatoprotection through the regulation of biliary epithelium barrier function.
Merlen G, Kahale N, Ursic-Bedoya J, Bidault-Jourdainne V, Simerabet H, Doignon I, Tanfin Z, Garcin I, Péan N, Gautherot J, Davit-Spraul A, Guettier C, Humbert L, Rainteau D, Ebnet K, Ullmer C, Cassio D, Tordjmann T.
Gut. 2020 Jan;69(1):146-157. doi: 10.1136/gutjnl-2018-316975. Epub 2019 Feb 5.

Publications 2018

The P2X4 purinergic receptor regulates hepatic myofibroblast activation during liver fibrogenesis.
Le Guilcher C, Garcin I, Dellis O, Cauchois F, Tebbi A, Doignon I, Guettier C, Julien B, Tordjmann T.
J Hepatol. 2018 Sep;69(3):644-653. doi: 10.1016/j.jhep.2018.05.020. Epub 2018 May 24. PMID: 29802948

Publications 2017

Bile acids and their receptors during liver regeneration: "Dangerous protectors".
Merlen G, Ursic-Bedoya J, Jourdainne V, Kahale N, Glenisson M, Doignon I, Rainteau D, Tordjmann T.
Mol Aspects Med. 2017 Aug;56:25-33. doi: 10.1016/j.mam.2017.03.002. Epub 2017 Mar 23. PMID: 28302491

Publications 2016

The P2X4 purinergic receptor impacts liver regeneration after partial hepatectomy in mice through the regulation of biliary homeostasis.
Besnard A, Gautherot J, Julien B, Tebbi A, Garcin I, Doignon I, Péan N, Gonzales E, Cassio D, Grosse B, Liu B, Safya H, Cauchois F, Humbert L, Rainteau D, Tordjmann T.
Hepatology. 2016 Sep;64(3):941-53. doi: 10.1002/hep.28675. Epub 2016 Jul 15. PMID: 27301647

Publications 2015

The Bile Acid Receptor TGR5 and Liver Regeneration.
Jourdainne V, Péan N, Doignon I, Humbert L, Rainteau D, Tordjmann T.
Dig Dis. 2015;33(3):319-26. doi: 10.1159/000371668. Epub 2015 May 27. PMID: 26045264.
Bile acids and FGF receptors: orchestrators of optimal liver regeneration.
Gilgenkrantz H, Tordjmann T.
Gut. 2015 Sep;64(9):1351-2. doi: 10.1136/gutjnl-2014-308746. Epub 2015 Feb 5. PMID: 25654989.
 
Pathophysiology and Treatment of Liver Diseases

Pathophysiology and Treatment of Liver Diseases

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